Nucleic Acids & Genome Architecture
A 16-module path through nucleic acids & genome architecture, in study order from foundations to the frontier.
Modules
- DNA vs RNA Chemistry
- Nucleotides and the Sugar-Phosphate Backbone
- Chargaff's Rules and Base Composition
- The Watson-Crick Double Helix Model
- Base Pairing and Antiparallel Complementarity
- Helical Geometry: Major and Minor Grooves
- DNA Conformations: A, B, and Z Forms
- The Meselson-Stahl Experiment
- DNA Supercoiling
- Topoisomerases and Linking Number
- Genome Organization Across Domains of Life
- Nucleosome Structure
- Histones and the Histone Code
- Chromatin Fiber and Higher-Order Folding
- Chromatin Remodeling
- Repetitive DNA and the C-Value Paradox