Spectroscopy & Structure Determination
A 23-module path through spectroscopy & structure determination, in study order from foundations to the frontier.
Modules
- The Logic of Structure Determination
- The Electromagnetic Spectrum and Molecular Energy Transitions
- Infrared Spectroscopy: Molecular Vibrations and the Harmonic Oscillator
- Hooke's Law: Predicting IR Frequencies from Mass and Bond Strength
- Diagnostic IR Functional-Group Frequencies
- The Carbonyl Region: Distinguishing Carbonyl Types by IR
- The Fingerprint Region and Interpreting Full IR Spectra
- Mass Spectrometry: Ionization and the Molecular Ion
- Isotope Patterns and Molecular Formula Determination
- Fragmentation Mechanisms and Diagnostic Losses
- The Physics of NMR: Nuclear Spin and Resonance
- Chemical Shift, Shielding, and the ppm Scale
- 1H NMR Chemical Shifts: Correlating Structure to Shift
- Magnetic Anisotropy: Aromatic, Alkene, and Aldehyde Shifts
- Integration: Counting Protons
- Spin-Spin Splitting and the n+1 Rule
- Coupling Constants (J) and Structural Information
- Diastereotopic Protons and Complex Splitting Patterns
- 13C NMR: Sensitivity, Shifts, and Signal Counting
- DEPT: Classifying Carbons by Attached Hydrogens
- Introduction to 2D NMR: COSY and HSQC
- UV-Vis Spectroscopy, Conjugation, and Chromophores
- Solving Combined-Spectra Problems