Substitution & Elimination
A 23-module path through substitution & elimination, in study order from foundations to the frontier.
Modules
- Alkyl Halide Structure and the C–X Bond
- Nomenclature and Classification of Alkyl Halides
- Nucleophiles, Electrophiles, and Curved Arrows
- Leaving Group Ability and Bond Strength
- The SN2 Mechanism: Backside Attack
- SN2 Kinetics and the Rate Law
- SN2 Stereochemistry and Walden Inversion
- Steric Effects and Substrate Structure in SN2
- Nucleophilicity versus Basicity
- Solvent Effects on Nucleophilicity
- Carbocation Stability and Structure
- The SN1 Mechanism and Ionization
- SN1 Kinetics and Solvolysis
- SN1 Stereochemistry and Racemization
- Solvent Effects on SN1 Ionization
- Predicting SN2 versus SN1: The Substrate Test
- Introduction to β-Elimination and Alkene Formation
- The E2 Mechanism
- E2 Anti-Periplanar Geometry
- Stereospecificity in E2 and Cyclohexane Systems
- The E1 Mechanism
- Zaitsev versus Hofmann Regiochemistry
- The Grand Summary: Predicting SN1/SN2/E1/E2