A synthesis step requires and must be driven by a reaction that does not involve…

CHEMISTRY · Single correct · AP · Chemistry · Thermodynamics and Electrochemistry · Thermodynamics and Electrochemistry

Problem

A synthesis step requires ΔG∘=+22.5 kJ mol−1\Delta G^{\circ}=+22.5\,\text{kJ\,mol}^{-1} and must be driven by a reaction that does not involve phosphate transfer. Which of the following reactions is most appropriate to couple directly to this step? (a) Hydrolysis of GTP to GDP + Pi\text{P}_{\mathrm{i}} ; ΔG∘=−30.5 kJ mol−1\Delta G^{\circ}=-30.5\,\text{kJ mol}^{-1} (b) Hydrolysis of acetyl-CoA to acetate + CoA ; ΔG∘=−31 kJ mol−1\Delta G^{\circ}=-31\,\text{kJ mol}^{-1} (c) Hydrolysis of succinyl-CoA to succinate + CoA ; ΔG∘=−15 kJ mol−1\Delta G^{\circ}=-15\,\text{kJ mol}^{-1} (d) Hydrolysis of creatine phosphate to creatine + Pi\text{P}_{\mathrm{i}} ; ΔG∘=−43.0 kJ mol−1\Delta G^{\circ}=-43.0\,\text{kJ mol}^{-1}

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