A polyglutamine peptide has Zimm-Bragg nucleation parameter .

PHYSICS · Multi-part · Fermi University Physics · Biophysics & Medical Physics · Macromolecules, membranes and cell architecture · Macromolecules, membranes and cell architecture

Forces, Machines and Signals, Ch Cooperativity: zippers, melting and allosteric binding

Problem

A polyglutamine peptide has Zimm-Bragg nucleation parameter σ=2.5×10−5\sigma = 2.5\times10^{-5}. ((a)) Find the slope of the helix fraction θ(s)\theta(s) at the midpoint s=1s=1. ((b)) Find the mean cooperative length (mean helix length) at the midpoint.

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