A single frozen particle image has signal-to-noise ratio
PHYSICS · Subjective · Fermi University Physics · Mathematical Methods for Physics · Biophysics & Medical Physics · Macromolecules, membranes and cell architecture
Forces, Machines and Signals, Ch Seeing molecules: diffraction, cryo-electron microscopy and fluorescence
Problem
A single frozen particle image has signal-to-noise ratio 0.020, too noisy to show any structural detail. Averaging N aligned, correctly classified images improves the signal-to-noise ratio by a factor of N. How many particle images must be averaged to reach a signal-to-noise ratio of 2.0?