An enzyme lowers the activation free energy for a reaction by at

PHYSICS · Multi-part · Fermi University Physics · Biophysics & Medical Physics · Molecular machines, transport and bioenergetics · Molecular machines, transport and bioenergetics

Forces, Machines and Signals, Ch Enzymes and molecular motors

Problem

An enzyme lowers the activation free energy for a reaction by 30 kJ mol−130\,\mathrm{kJ\,mol^{-1}} at 298 K298\,\mathrm{K}, leaving the equilibrium constant unchanged. The uncatalysed rate constant is 1.0×10−3 s−11.0\times10^{-3}\,\mathrm{s^{-1}}. ((a)) Find the rate enhancement factor produced by this barrier reduction. ((b)) Find the catalysed rate constant.

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