A patch-clamp recording of a single ion channel lasts in total

PHYSICS · Multi-part · Fermi University Physics · Biophysics & Medical Physics · Molecular machines, transport and bioenergetics · Molecular machines, transport and bioenergetics

Forces, Machines and Signals, Ch Channels, pumps and the resting potential

Problem

A patch-clamp recording of a single ion channel lasts

5.0\,\mathrm{s}

in total. Over that time the channel is open for a total of

1.35\,\mathrm{s}

, resolved as

45

separate opening events. The channel obeys simple two-state (open/closed) kinetics, and the record also contains

45

closed intervals. ((a)) Find the open probability

P_o

of the channel. ((b)) Find the mean open dwell time

\tau_{\rm open}

. ((c)) Find the mean closed dwell time

\tau_{\rm closed}

Browse the problem library