Acids, Bases & Reactivity Fundamentals
A 24-module path through acids, bases & reactivity fundamentals, in study order from foundations to the frontier.
Modules
- Bronsted Acids and Bases in Organic Chemistry
- Conjugate Acid-Base Pairs and Reaction Direction
- The Curved-Arrow Formalism
- Double- versus Single-Barbed (Fishhook) Arrows
- Homolytic versus Heterolytic Bond Cleavage
- Defining pKa and the Acidity Constant
- Predicting Equilibrium Position from pKa
- Stability of the Conjugate Base as the Master Principle
- Electronegativity and Atom Size Across the Periodic Table
- Inductive Effects on Acidity
- Resonance Delocalization and Acidity
- Hybridization Effects on Acidity
- Solvation Effects on Acidity
- Combining Effects to Rank Acidity
- Carboxylic Acids: A Case Study in Combined Effects
- Using pKa Tables Quantitatively
- Choosing a Base for a Given Deprotonation
- Lewis Acids and Bases
- Nucleophiles versus Electrophiles
- Basicity versus Nucleophilicity
- Reactive Intermediates: Overview and Classification
- Reaction Energy Profiles
- Thermodynamic versus Kinetic Control
- The Hammond Postulate