Enols, Enolates & Alpha-Carbon Chemistry
A 24-module path through enols, enolates & alpha-carbon chemistry, in study order from foundations to the frontier.
Modules
- Acidity of the Alpha C–H Bond
- Keto-Enol Tautomerism
- Acid- and Base-Catalyzed Enolization Mechanisms
- Enol Content and Structural Effects
- Enolate Formation and Structure
- Choice of Base: Thermodynamic vs Kinetic Enolates
- Regiochemistry of Unsymmetrical Ketone Enolates
- Enolate Geometry: E and Z Enolates
- Ambident Reactivity: C- vs O-Alkylation
- Enolate Alkylation
- Alpha-Halogenation Under Acidic Conditions
- Base-Promoted Halogenation and the Haloform Reaction
- Hell-Volhard-Zelinsky Reaction
- The Aldol Reaction
- Aldol Condensation and Dehydration
- Crossed (Mixed) Aldol Reactions
- Directed Aldol Using Preformed Enolates
- Stereochemistry of the Aldol Reaction
- The Claisen Condensation
- Crossed Claisen Condensations
- The Dieckmann Condensation
- The Michael Addition
- Malonic and Acetoacetic Ester Syntheses
- The Robinson Annulation